Patients with McCune�Albright syndrome are predisposed to pancreatic cancer
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چکیده
منابع مشابه
Mice with the CHEK2*1100delC SNP are predisposed to cancer with a strong gender bias.
The CHEK2 kinase (Chk2 in mouse) is a member of a DNA damage response pathway that regulates cell cycle arrest at cell cycle checkpoints and facilitates the repair of dsDNA breaks by a recombination-mediated mechanism. There are numerous variants of the CHEK2 gene, at least one of which, CHEK2*1100delC (SNP), associates with breast cancer. A mouse model in which the wild-type Chk2 has been repl...
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ژورنال
عنوان ژورنال: International Journal of Case Reports and Images
سال: 2017
ISSN: 0976-3198
DOI: 10.5348/ijcri-201710-ed-10011